Endocrine Abstracts

Aim of the study was to evaluate whether clinical parameters and echographic patterns may be predictive of malignancy in thyroid nodules with a cytological diagnosis of follicular (FOL) and H?rthle cell (HC) neoplasia. The study included 495 patients (388 F: mean age 45±14 yr; 107 M: mean age 46±14 yr) with FOL (n=418) and CH (n=77) nodules, ‘cold’ at scintiscan and undergone to thyroidectomy. Clinical parameters considered were: sex, age, goi...

Introduction: Continuous Subcutaneous Insulin Infusion (CSII) has several advantages over Multiple Daily Injections (MDI) including better hourly delivery and avoidance of injections. However usage of CSII is significantly less in Cystic Fibrosis Related Diabetes (CFRD) compared to type 1 diabetes and published literature on use of CSII in children and adolescents with CFRD is minimal.We report two cases where CSII was used in CFRD resulting in a lower T...

Introduction: Enteroendocrine cells (EECs) are hormone-secreting cells within the intestinal epithelium that play an important role in regulating food absorption, insulin secretion and appetite. To understand the molecular mechanism governing the function of EECs, it is important to investigate cell-type-specific gene expression. The aim of this study was to identify the transcriptome of human EEC populations from organoid culture.Methods: To label the f...

Epidermal growth factor (EGF) and heregulin (HRG) act via ErbB receptors, to stimulate Akt and ERK. These drive breast cancer cell proliferation and the network is targeted in cancer therapy (1). Single cell responses show marked cell-cell variation and information theory provides statistical measures that take the effect this noise has on information transfer into account (2). Here we quantify the mutual information (MI) between stimulus concentration and effects in MCF7 cell...

Aim: To assess the relation between questionnaires of androgenic function (AMS and IIEF-EF scores) and sex hormones (DHT, estradiol and total and free testosterone) in men attending an outpatient clinic for endocrine and reproductive disorders.Methods: We retrospectively reviewed all data entered in the electronic database of the Münster Center of Reproductive Medicine and Andrology (CeRA) Androbase from patients visited between January 2015 and Oct...

Background: Recent consensus recommends assessment of aortic dimensions with aortic sized index (ASI) normalized for body surface area (BSA) defined as absolute aortic dimension/BSA, in girls with Turner syndrome (TS) as young as 10 years. There are currently multiple formulae for estimating BSA without agreement on a preferred method. We assess the clinical validity of each formulae as this may have implications on interpretation of ASI.Method: We calcu...

Thyroidectomy is the definitive treatment for toxic multinodular goiter (TXMNG). Surgery should be performed when the patient is euthyroid which decreases perioperative cardiac risks. Plasmapheresis is a procedure that removes the thyroid hormones from the circulation. It is an alternative method in case of resistance or contraindications to anti thyroid drugs. Role of plasmapheresis in the treatment of TXMNG is not fully determined in the literature. We report a case with TXM...

A 42-year-old man with resistance to thyroid hormone (RTH) and a recognised thyroid hormone receptorβ mutation (R383C) mutation, presented with atrial fibrillation (AF) which was resistant to DC cardioversion until initiation of amiodarone therapy.As expected in RTH, his baseline TFTs were abnormal (FT4 34.6 pmol/l, TSH 2.27 mU/l), but rose further (FT4 45 pmol/l, TSH 0.93 mU/l) following commencement of amiodarone. However, sh...

Introduction: Klinefelter Syndrome (KS; 47,XXY) is the most common sex chromosome disorder in men, characterized by hypergonadotropic hypogonadism. EXAKT (Epigenetics, X-chromosomal features and clinical Applications in Klinefelter syndrome Trial) is a Muenster-based prospective project involving Klinefelter patients and their parents assessing a wide area of cardiovascular, inflammatory and metabolic factors as well as a broad range of genetic and epigenetic investigations es...

Effects of sugar cane extract (SCE) on the adrenal corticosterone and progesterone secretion in male rats were investigated using an in vitro cell culture system. Three-week old male rats were fed SCE free diet or 2.16% SCE diet for 7 weeks. After 7 weeks of treatment, animals were decapitated, and adrenal cells were cultured in the absence or presence of rat ACTH (10–15 to 10-10 M) for 4 hours. Body and adrenal gland weight, plasma concentration of ACTH, corticost...